Bundibugyo Ebola outbreak in DRC: clinical guidance for UK clinicians (bmj.com)

• WHO declared PHEIC on 17 May; >1200 cases and 250 deaths in DRC and Uganda.
• Bundibugyo virus lacks a licenced vaccine; existing vaccines may be less effective.
• UK clinicians: use risk assessment algorithm, contact HCID centres for confirmed cases.
• Clinical trials underway for remdesivir and monoclonal antibodies (MBP134).
• International travel restrictions imposed; UK risk remains low.

"The 2026 Ebola outbreak in the Democratic Republic of the Congo (DRC), caused by the Bundibugyo virus, has been declared a Public Health Emergency of International Concern by WHO. As of 27 May, over 1200 cases and 250 deaths have been reported. This article provides practical guidance for UK clinicians on identifying and managing suspected cases, including risk assessment algorithms and contact with specialist centres. It notes low risk to the UK, no licenced vaccine for this strain, and ongoing trials for treatments (remdesivir, monoclonal antibodies) and vaccines (ChAdOx1 Bundibugyo, rVSV Bundibugyo). International travel restrictions are discussed."