ICTV Report: Orthoebolavirus Genus Taxonomy and Virology (ictv.global)

• Six species in genus Orthoebolavirus.
• EBOV and SUDV are highly lethal human pathogens.
• Genome: ~18.9 kb negative-sense RNA, seven structural proteins.
• Glycoproteins are heavily glycosylated and antigenically diverse.
• Bats suspected natural hosts; RESTV also infects pigs.

"The ICTV Report chapter on the genus Orthoebolavirus details six species, including Ebola virus (EBOV) and Sudan virus (SUDV), which are highly lethal human pathogens. Bombali virus (BOMV) may not be pathogenic. Virions are filamentous, with a negative-sense RNA genome of ~18.9 kb encoding seven structural proteins. Glycoproteins are heavily glycosylated and antigenically diverse. Human-to-human transmission occurs via direct contact with bodily fluids. Bats are suspected natural hosts; RESTV also infects pigs."